CMCF - Canadian Macromolecular Crystallography Facility

CMCF is an umbrella facility which operates two beamlines, CMCF-ID and CMCF-BM, at the Canadian Light Source. Together, both beamlines enable high-resolution structural studies of proteins, nucleic acids and other macromolecules, satisfying the requirements of the most challenging and diverse crystallographic experiments.

Spectral Range

5-20 keV 6-19 keV


  • Single-crystal X-ray diffraction
  • Single/Multi-wavelength Anomalous Dispersion (SAD/MAD)
  • Single-crystal X-ray diffraction
  • Single/Multi-wavelength Anomalous Dispersion (SAD/MAD)
  • Metal identification on crystals
  • Metal identification on crystals
X-ray Absorption Spectroscopy (XAS)
  • XANES & EXAFS on crystals


Typically, samples are crystallized macromolecules mounted on standard MX sample pins.

Most experiments are performed at LN2 temperatures, but room temperature and humidity-controlled experiments are also available.




CLS Port 08ID-1 08B1-1
Source Insertion Device: Undulator Bending Magnet
Typical spot sizes 5-50 μm 20, 50, 100, 150, 200 μm
Maximum Photon Flux 1x1013 @ 12 keV 
1x1014 in pink-beam mode 
1 x 1011 @ 12 keV
1 x 1012 in pink-beam mode
Automounter ISARA: ~30s per sample change SAM: ~30s per sample change


Michel Fodje Senior Scientist, Beamline Responsible (CMCF)

Miroslaw Cygler CMCF Beamline Advisory Team Leader

Visit the CMCF website for a full list of beamline contacts.

Full Contact List

Beamline Video

Learn all about the CMCF-BM beamline from Kathryn Janzen, associate scientist.


Purchased Access

Purchased access offers quick and accurate solutions to proprietary questions. CLS scientists develop an experimental plan based on the client’s needs, and conduct all data collection and analysis, resulting in a detailed report with key answers to critical questions.

Learn More

Peer-Reviewed Access

Academic clients can submit proposals through a peer review process. Beam time is granted based on scientific merit, with the expectation that any results will be published. In special cases, rapid access is also available for instrument or beam time.

Proposal Submission