Biomedical Imaging and Therapy

Overview

Biomedical Imaging and Therapy facility is a set of two beamlines designed to support a wide variety of programs in the life sciences by providing outstanding possibilities for pre-clinical and biomedical imaging. The versatility of BMIT imaging stations also allows to study various problems of material science, energy, environment, cultural heritage, and others scientific areas.

The powerful 05ID-2 wiggler beamline delivers X-ray beam with the photon flux density sufficient to acquire monochromatic CT set in five to ten minutes in most cases. Spectral range extends to 140 keV, which can be used to study larger animal models such as piglets and, in general, penetrate through thick, absorbing samples. Beamline supports propagation-based phase contrast imaging which in many cases allow samples to be visualized in ways not possible using conventional clinical devices and laboratory microCT systems.

Please discuss details of your proposal with the beamline scientist prior to submitting your proposal.

 

  • Status

    Accepting Proposals

  • Resolution ΔE/E @ E

    ~ 5x10-3 @ 30 keV

  • Source Size (Horizontal x Vertical)

    1.0 mm x 0.1 mm @ FWHM

  • Beam Size at sample (Horizontal x Vertical)

    100 mm x 10 mm @FWHM @ 30 keV

  • Energy Range

    30 - 140 keV

  • Photon Flux

    Flux ~5x1010 phot/mm2/sec

Techniques:

  • Computed (micro)Tomography (CT/µCT)
  • Irradiation experiments
  • Contrast mechanisms:
    • Propagation-based phase contrast (PBI)
    • K-edge Subtraction Imaging (KES)

Endstations & Capabilities

  • Up to four heavy duty positioning stages are available for positioning of detector, sample, and auxiliary equipment to create complex experimental environments.

  • Because of the large source size propagation-based phase-contrast and TIE/Paganin phase retrieval are possible at high spatial resolutions and short propagation distances only

Detector Pool


Optics

Wiggler → Heat removal filters → Bent Laue-Laue mono → Imaging stations @ 50-60m

Contacts

Beamline Responsible: Sergey Gasilov (306) 657-3643
Beamteam Leader: David Cooper, College of Medicine, University of Saskatchewan
Full list: https://bmit.lightsource.ca/contact-us/

Sergey Gasilov, 306-657-3643 with questions about instruments, techniques, and data reconstruction
Denise Miller, 306-657-3815 regarding scheduling, beamtime cancellation, etc.
Arash Panahifar, 306-657-3808 about experiments with live animals including care, protocols, ethics, labs
Ning Zhu, 306-657-3589 for drawings of mounting interfaces, adapters, need for unusual sample holders, etc.
  • Front row: Ning Zhu, David Cooper (BMIT BeamTeam Leader), Adam Webb, Dean Chapman (Science Director)
    Back row: Sergey Gasilov, Denise Miller

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