Biomedical Imaging and Therapy

Overview

Biomedical imaging and Therapy facility is a set of two beamlines designed to support a wide variety of programs in the life sciences by providing outstanding possibilities for pre-clinical and biomedical imaging. The versatility of BMIT imaging stations also allows to study various problems of material science, energy, environment, cultural heritage, and others scientific areas.

BMIT bending magnet beamline generates X-rays in the energy range 12.6-40 keV which is optimal for imaging of lightweight materials and of small animals such as mice. Owing to the exceptional stability of the beam, crystal-based imaging modalities such as K-edge spectral imaging and analyzer crystal based imaging can be employed. Access to the white beam enables imaging with high spatio-temporal resolution (CT snapshot in less than 10 sec) and high throughput screening.

Please discuss details of your proposal with the beamline scientist prior to submitting your proposal.

  • Status

    Operational

  • Resolution ΔE/E

    dE/E≤10-3 mono beam
    dE/E~0.1 filtered white beam

  • Source Size

    ~0.60 mm x 0.14 mm @FWHM      

  • Beam Size at Sample

    100 mm x 4 mm @FWHM @ 20 keV  

  • Energy Range

    12.6-40.0 keV

  • Photon Flux

    109 phot/mm2/sec mono beam
    up to 1012 phot/mm2/sec in filtered white beam

Techniques:

  • Computed tomography and microtomography
  • Computed laminography
  • White beam access:
    • Ultrafast and time-resolved radiography and tomography
    • Rocking curve imaging
    • Spectral K-edge imaging
  • Analyzer crystal based imaging
  • K-edge subtraction imaging

Contrast mechanisms

  • Absorption
  • Propagation-based phase contrast
  • Unidirectional first-derivative phase-contrast
  • Ultra-small angle scattering/dark field
  • K-edge sensitivity for selected elements

BMIT-BM Endstations & Capabilities

  • X-ray (micro)tomography end station. An ample amount of space and a heavy duty positioning stage (sample weight up to 20 kg) are available for complex experiments such as live animal studies, in-situ and in-operando imaging.
  • Phase-contrast based on propagation and TIE/Paganin phase retrieval
  • Access to filtered white beam for imaging of dynamic processes (4D CT) and high-throughput scanning
  • Multi-contrast imaging with analyzer crystal (Si 220 Bragg geometry)
  • Spectral and K-edge imaging with bent Laue crystals
Please visit https://bmit.lightsource.ca/publications/ for examples of research performed at BMIT

Optics

Bending magnet → Al and K-edge filters → Bragg-Bragg DCM (optional) → Imaging stations @ 21-26m

Detector Pool

Please refer to https://bmit.lightsource.ca/tech-info/detectors/ for information about the pixel size and field of view

Contacts

Beamline Responsible: Sergey Gasilov 306-657-3643
Beamteam Leader: David Cooper, College of Medicine, University of Saskatchewan
Full list: https://bmit.lightsource.ca/contact-us/
 
Sergey Gasilov - 306-657-3643 - with questions about instruments, techniques, and feasibility of various projects
Arash Panahifar - 306-657-3808 - regarding scheduling, beamtime cancellation, and live animal experiments
Ning Zhu - 306-657-3835 - for drawings of mounting interfaces, adapters, unusual sample holders, etc.
Adam Webb - 306-657-3835 - data reconstruction, transfer, and storage
Toby Bond - 306-657-3835 - for information about industrial services, paid access, mail-in program
 
  • Front row: Ning Zhu, David Cooper (BMIT BeamTeam Leader), Adam Webb, Dean Chapman
    Back row: Sergey Gasilov, Denise Miller

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