Biomedical Imaging and Therapy

Overview

Biomedical imaging and Therapy facility is a set of two beamlines designed to support a wide variety of programs in the life sciences by providing outstanding possibilities for pre-clinical and biomedical imaging. The versatility of BMIT imaging stations also allows to study various problems of material science, energy, environment, cultural heritage, and others scientific areas.

BMIT bending magnet beamline generates X-rays in the energy range 12.6-40 keV which is optimal for imaging of lightweight, small samples and of little animals such as mice. Owing to the exceptional stability of the beam, crystal-based imaging modalities such as K-edge spectral imaging and analyzer based imaging can be employed. Access to the white beam enables imaging with high spatio-temporal resolution (CT snapshot in less than 10 sec) and high throughput screening.

Please discuss details of your proposal with the beamline scientist prior to submitting your proposal.

  • Status

    Accepting Proposals

  • Resolution ΔE/E

    dE/E≤10-3 mono beam
    dE/E~0.1 filtered white beam

  • Source Size (Horizontal x Vertical)

    ~0.60 mm x 0.14 mm @FWHM      

  • Beam Size at sample (Horizontal x Vertical)

    100 mm x 4 mm @FWHM @ 20 keV  

  • Photon Flux

    109 phot/mm2/sec mono beam
    1012 phot/mm2/sec filtered white beam @ 20 keV

Endstation(s):

  • Custom positioning system. Max. load capacity 50 kg.
 

Techniques:

  • Computed tomography and microtomography
White beam access:
  • Ultrafast and time-resolved radiography and tomography
  • Rocking curve imaging
  • Spectral K-edge imaging
Analyzer crystal based imaging
K-edge subtraction imaging

Contrast mechanisms:

  • Absorption
  • Propagation-based phase contrast
  • Unidirectional first-derivative phase-contrast
  • Ultra-small angle scattering/dark field
  • K-edge sensitivity for selected elements

BMIT-BM Endstations & Capabilities

  • Custom positioning system. Max. load capacity 50 kg.
  • X-ray (micro)tomography end station. An ample amount of space and a heavy duty positioning stage (sample weight up to 20 kg) are available for complex experiments such as live animal studies, in-situ and in-operando imaging.
  • Phase-contrast based on propagation and TIE/Paganin phase retrieval
  • Access to filtered white beam for imaging of dynamic processes (4D CT) and high-throughput scanning
  • Multi-contrast imaging with analyzer crystal (Si 220 Bragg geometry)
  • Spectral and K-edge imaging with bent Laue crystals

Optics

Bending magnet  Al and K-edge filters  Bragg-Bragg DCM (optional)  Imaging stations @ 21-26m

Contacts

Beamline Responsible: Sergey Gasilov (306) 657-3643
Beamteam Leader: David Cooper, College of Medicine, University of Saskatchewan
Full list: https://bmit.lightsource.ca/contact-us/
 
Sergey Gasilov - 306-657-3643 - with questions about instruments, techniques, and data reconstruction
Denise Miller - 306-657-3815 - regarding scheduling, beamtime cancellation, etc.
Arash Panahifar - 306-657-3808 - about experiments with live animals including care, protocols, ethics, labs
Ning Zhu - 306-657-3589 - for drawings of mounting interfaces, adapters, need for unusual sample holders, etc.

Detector Pool


*Vertical FOV is limited by the beam divergence. FWHM of monochromatic beam is given. In filtered white beam mode, vertical FWHM decreases to 3mm
  • Front row: Ning Zhu, David Cooper (BMIT BeamTeam Leader), Adam Webb, Dean Chapman
    Back row: Sergey Gasilov, Denise Miller

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