All research performed at the Canadian Light Source facility (CLS) that involves: human subjects and/or the use of human tissue or biological fluids from subjects, living or not, or live animals and/or animal tissue or biological fluids from animals requires ethics approval prior to performing research at the CLS.
The CLS facility is licensed through the Canadian Nuclear Safety Commission (CNSC) and CLSI is required to comply with all applicable federal, provincial and municipal laws. CLSI is a wholly owned subsidiary of the University of Saskatchewan.
The University of Saskatchewan:
- follows the national standards outlined by the Tri-Council Policy Statement: Ethical Conduct for Research Involving Humans and the University Policy Research Involving Human Subjects. The Tri-Council Policy Statement expresses the commitment to the people of Canada to promote the ethical conduct of research involving human subjects.
- holds the Canadian Council on Animal Care (CCAC) Certificate of Good Animal Practice, indicating that it is in compliance with the national standards set by the CCAC.
Ethics Approval Requirements
- All Certificates must reference the planned use of the CLS facility. If an ethics certificate already exists without the mention of the use of the CLS, an amendment to the ethics certificate must be made.
- Unsure if ethics is required? Contact University of Saskatchewan Research Ethics Office:
Human subjects (living or not), human biological materials derived from living or deceased individuals or cell lines
- Examples: Living human participants; human cell lines; embryos; fetuses; fetal tissue; reproductive materials; stem cells; bones, hair, skin, human waste.
- Exemptions: Research that relies exclusively on publicly available information does not require REB review when: a) the information is legally accessible to the public and appropriately protected by law; or b) the information is publicly accessible and there is no reasonable expectation of privacy.
- Action required: attach a valid certificate of Research Ethics Approval from the University of Saskatchewan Biomedical Research Ethics Board (REB). If you are not affiliated with the University of Saskatchewan (UofS) please attach an equivalent Certificate of Ethics Approval and Researcher's Summary Form from your home institute. All non UofS affiliated users will have their CLS proposal and supporting ethics documents forwarded to the appropriate UofS Research Ethics Board (REB) for review. If additional information is required, the UofS REB will correspond directly with you.
- Examples: Animals - use of non-human vertebrates and cephalopods (fishes, amphibians, reptiles, birds and mammals)
- Exemptions: None
- Action Required: attach a valid Animal Use Protocol (AUP) Certificate of Approval from the University of Saskatchewan (UofS). If you are not affiliated with the University of Saskatchewan (UofS) please attach a valid Certification of Approval from your home institute. UofS Animal Research Ethics Board (AREB) will review the home institution’s AUP, i.e. submission of a new AUP form is not required.
- Note: UofS Clinical Veterinarian to be on-site at CLS during the scheduled experiment (to provide assistance with anesthetic and monitoring of experimental procedures.)
Animal tissue or biological fluids from animals
- Examples:use of tissue culture; use of tissues obtained at necropsy, from a slaughterhouse, or from another research scientist; or the use of eggs. Studies using most invertebrates (except cephalopods and some other higher invertebrates) or on live isolates, such as protozoa or other single-celled organisms, do not need to be submitted for ethics review.
- Exemptions: Animal cell lines purchased from a commercial vendor (e.g. Ward’s Science, samples obtained from the UCACS Tissue Databank) do not need ethics, however, do need to be identified on the application.
- Action Required: attach a Valid UofS AUP Category A Short Form
NOTE: The CLS maintains an approved AUP to cover the use of various animal tissues and other samples. Samples utilized under this AUP do not require additional approval, however, must be listed and the certificate number entered on your form. Please click here to view AUP.
Review of ethics documents may take several weeks. Ethics approval for experiments involving live animals may take several months.