Synchrotron Protein Crystallography

Friday, June 16, 2006 (Full Day Workshop)

Protein crystallography (PX) is a powerful technique for solving biological problems at the molecular level. It increases our understanding of the structural basis of basic biological and biochemical principles and is essential to the design and optimization of ligands that bind to macromolecules in the pharmaceutical industry.

This workshop will focus on both communicating recent research results and discussing techniques of beamline development, data collection, processing, solving structures and user access, including applications at the CLS protein crystallography beamline. Additionally there will be presentations demonstrating the synergistic advantages of combining PX and SAXS in approaching biological problems.

Workshop Organizer: Pawel Grochulski, Canadian Light Source Inc.

Location:      Arts 134

Time

Speaker

Affiliation

Title
8:00-16:30 Registration Geology Atrium

8:30

Opening Remarks and Introduction to CMCF (Pawel Grochulski, CLS)

8:40

Paul Adams

Advanced Light Source, Lawrence Berkeley National Laboratory

Automated structure determination with PHENIX

9:20

Mirek Cygler

Biotechnology Research Institute, National Research Council of Canada

Structural Characterization of E. coli Histidine Synthesis Pathway

10:00

Coffee Break Geology Atrium

10:30

Robert Fischetti

Advanced Photon Source, Argonne National Laboratory

GM/CA Canted Undulator Beamlines for Macromolecular Crystallography: Design and Performance

11:10

Andrzej Joachimiak

Advanced Photon Source, Argonne National Laboratory

Structural Genomics combines genomic data and structural biology to advance protein fold and function space

11:50

Andrzej Joachimiak

Advanced Photon Source, Argonne National Laboratory

The Structural Biology Center beamlines at the Advanced Photon Source

12:20

Lunch Geology Atrium

13:40

Yu Luo

Department of Biochemistry, University of Saskatchewan

Novel insight from crystallographic studies on an archaeal RadA recombinase

14:20

Bhushan Nagar

Department of Biochemistry, McGill University

Structural basis for the autoinhibition and activation of c-Abl tyrosine kinase

15:00

Coffee Break Geology Atrium

15:30

Scott Williams

Department of Chemistry, The Scripps Research Institute

Assembled Structure of the Mre11/Rad50/DNA complex from X-ray Solution Scattering and Crystallography

16:10

Jurgen Sygusch

Department of Biochemistry, Université de Montréal

Cryotrapping of reaction intermediates – structural exploration of catalysis

16:50

Workshop Adjournment



Program Related Inquiries to: Pawel Grochulski pawel.grochulski@lightsource.ca

This workshop was organized and sponsored by the Canadian Light Source and the Canadian Federation of Biological Societies.

CLS CFBS

Support for this workshop is provided in part by the
Saskatchewan Health Research Foundation and the Molecular Design Research Group.

SHRF

Last modified: 2009-04-22 11:04:30

Canadian Light Source