Single crystal X-ray crystallography is a primary means of determining the molecular conformations of proteins and other biomolecules. It is thus critical for such applications as intelligent drug design and the characterization of medically-important effector targets.
The CLS boasts a highly-productive insertion device beamline (08ID-1) as well as a bending magnet beamline (08B1-1) with advanced capabilities that go beyond protein crystallography. Both beamlines are fully-equipped with on-axis visualization and the Stanford Automated Mounting System (SAM) allowing on-site or remote access. The facility has efficient software for sample and experiment tracking, data collection as well as an automated data processing pipeline. A humidity control device is available for controlled crystal dehydration experiments.
- Single crystal X-ray crystallography for determining detailed structures of proteins and other molecules.
- Determining protein structures with bound ligands for rational drug design.
- Structural proteomics.
- X-ray absorption spectroscopy (XAS), allowing high-resolution Extended X-ray Absorption Fine Structure (EXAFS) experiments on crystals to characterize metal centres.
- Rapidly analyzing multi-component mixtures using powder diffraction methods to design pharmaceutical formulations and improve drug delivery systems.
Discover our areas of expertise
- Unique-in-Canada analytical services:
- Advanced X-ray imaging
- Non-destructive testing
- In-situ investigations
- Bulk and surface investigations
- A strong team of accomplished scientists to work with you to develop scientific experiments that meet industry standards
- A full range of access modes to suit your needs
- Remote data collection from anywhere in the world
- On-site data collection, taking advantage of Saskatoon’s central location
- Mail-in service, where competent staff perform experiments for you
- Expertise across the scientific spectrum
- Leading-edge research and development
- A trusted reputation