01 Jul 2014

July 2014 E- News

  1. Call for proposals opens today, Tuesday, July 29
  2. 2014 election results for the Users' Advisory Committee
  3. CLS proud sponsor of Nature Milestones: Crystallography
  4. Structural Delineation of a Quaternary, Cleavage-Dependent Epitope at the gp41-gp120 Interface of Intact HIV-1 Trimers
  5. Bornstein sculpture reinstalled outside of CLS
  6. Now hiring 

1. Call for proposals opens today, Tuesday, July 29

Cycle 21 call for proposals will open today, Tuesday, July 29, for scheduling of beam time for the January-June, 2015 period. The deadline for proposals is Thursday September 4, 2014 – NOON (CST)

The schedule can be viewed on our website and beamlines participating in the call here.

General User Proposals are reviewed for safety and technical feasibility, and scored for scientific merit by an external review committee. Research time obtained through this competitive peer review process takes place twice per year. General User research should result in the publication of scientific results. You have the option of submitting a new proposal or submitting a beam time request against an active proposal. Allocation of shifts for January - June, 2015 will be based on the highest ranked proposals (both new and active).

To view evaluation criteria used in reviewing and rating proposals click here, or to compare your score to others please visit the website.

In addition to normal mode operations at 250 mA, six shifts for Coherent Synchrotron Radiation studies will be available, and must be applied for through the general user program.

For more information, please visit our website.

2. 2014 election results for the Users' Advisory Committee

The results are in for the 2014 AUC election. Rob Scott (University of Saskatchewan), Robert McKellar (National Research Council), and Aimy Bazylak (University of Toronto) have been elected to the UAC to serve three-year terms beginning in September.

Mercedes Martinson (U of S) has been elected as a student member, serving a two-year term.

The new Chair and Vice Chair for the UAC (2014-15) are, respectively, Andrew Grosvenor (U of S) and Jeff Warner (Cameco Corp.). Both terms begin September 1.

The following regular members' terms ended August 2014: Ken Burch (Boston College), Kirk Michaelian (Natural Resources Canada), and Jennifer van Wijngaarden (University of Manitoba). The UAC and CLS thank these individuals for their service to the user community and their work on behalf of the facility.

For more information, contact the CLS Users' Office, or visit the UAC page.

3. CLS proud sponsor of Nature Milestones: Crystallography

The CLS and a group of lightsource facilities around the world are proud sponsors of special issue ofNature Milestones: Crystallography.

Crystallography tells us how atoms are arranged in solids and is essential for our understanding of the material world.

The UNESCO 2014 International Year of Crystallography commemorates not only the centennial of X-ray diffraction, which allowed the detailed study of crystalline material, but also the 400th anniversary of Kepler’s observation in 1611 of the symmetrical form of ice crystals, which began the wider study of the role of symmetry in matter.

There is also a timeline to highlight crystallography's defining moments in Scientific American that has been adapted from Nature Milestones.

For more information on crystallography experiments at the CLS, visit the CMCF website.

4. Structural Delineation of a Quaternary, Cleavage-Dependent Epitope at the gp41-gp120 Interface on Intact HIV-1 Env Trimers

All previously characterized broadly neutralizing antibodies to the HIV-1 envelope glycoprotein (Env) target one of four major sites of vulnerability. Here, the authors define and structurally characterize a unique epitope on Env that is recognized by a recently discovered family of human monoclonal antibodies (PGT151–PGT158). The PGT151 epitope is comprised of residues and glycans at the interface of gp41 and gp120 within a single protomer and glycans from both subunits of a second protomer and represents a neutralizing epitope that is dependent on both gp120 and gp41. Because PGT151 binds only to properly formed, cleaved trimers, this distinctive property, and its ability to stabilize Env trimers, has enabled the successful purification of mature, cleaved Env trimers from the cell surface as a complex with PGT151. The authors compare the structural and functional properties of membrane-extracted Env trimers from several clades with those of the soluble, cleaved SOSIP gp140 trimer.

Blattner, Claudia, et al. "Structural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimers." Immunity 40.5 (2014): 669-680. DOI: 10.1016/j.immuni.2014.04.008

5. Bornstein sculpture reinstalled outside of CLS

A major abstract work – hexaplane structurist relief No. 3, 2001-2003 – by noted international artist Eli Bornstein has been reinstalled outside of the CLS.

Read the complete story on the Bornstein sculpture in On Campus News.

For more images of Bornstein and the sculpture, visit the CLS Flickr Gallery.

 

 

 

 

6. Now hiring

The following job postings are currently available at CLS:

Job No. 761 - Casual Student Floor Coordinators
Job No. 760 - Geomicrobiology Graduate Student Research Opportunities
Job No. 759 - Staff Scientist – Mid-Infrared Beamline

Please visit our careers page for more information.

 


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