01 Aug 2014

August 2014 E-News

  1. Call for proposals closes Thursday, September 4
  2. 2013-2014 Annual Highlights now available
  3. CLS on display at Nuit Blanche Saskatoon, September 27
  4. Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs 
  5. New synchrotron imaging technique reveals how cystic fibrosis makes lungs vulnerable to infection
  6. Research gives further insight into graphene-based devices
  7. An interesting glimpse into how future state-of-the-art electronics might work
  8. New staff and now hiring 

1. Call for proposals closes Thursday, September 4

Cycle 21 call for proposals for scheduling of beam time for the January-June, 2015 period closes Thursday September 4, 2014 – NOON (CST)

The schedule can be viewed on our website and beamlines participating in the call here. 

General User Proposals are reviewed for safety and technical feasibility, and scored for scientific merit by an external review committee. Research time obtained through this competitive peer review process takes place twice per year. General User research should result in the publication of scientific results. You have the option of submitting a new proposal or submitting a beam time request against an active proposal. Allocation of shifts for January - June, 2015 will be based on the highest ranked proposals (both new and active).

To view evaluation criteria used in reviewing and rating proposals click here, or to compare your score to others please visit the website. 

In addition to normal mode operations at 250 mA, six shifts for Coherent Synchrotron Radiation studies will be available, and must be applied for through the general user program.

2. 2013-2014 Annual Highlights now available  

The 2013-2014 CLS Annual Highlights report is now available.

In the document, you will find facts and figures about the CLS, interesting science highlights, as well as our financial statements for the 2013-2014 fiscal year.

Download the pdf from our website.    

 

 

 

 

3. CLS on display at Nuit Blanche Saskatoon, September 27 

Nuit Blanche is a night-time art festival that began in Nantes, France in 1984 and has since spread to cities all over the world. 

The first ever Nuit Blanche Saskatoon will feature an exhibit of imagery, animation, and sound projections from the CLS. 
 
CMCF scientistsKathryn Janzen and Shaun Labiuk, along with staff communications coordinator Mark Ferguson, have created an interactive exhibit of crystallography images and animations of protein structures mapped at the CLS. 

4. Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs   

The Cul4–?Rbx1–?DDB1–?Cereblon E3 ubiquitin ligase complex is the target of ?thalidomide, ?lenalidomide and ?pomalidomide, therapeutically important drugs for multiple myeloma and other B-cell malignancies. These drugs directly bind ?Cereblon (?CRBN) and promote the recruitment of substrates ?Ikaros (?IKZF1) and ?Aiolos (?IKZF3) to the E3 complex, thus leading to substrate ubiquitination and degradation. Chamberlain et al. present the crystal structure of human ?CRBN bound to ?DDB1 and the drug ?lenalidomide. A hydrophobic pocket in the thalidomide-binding domain (TBD) of ?CRBN accommodates the ?glutarimide moiety of ?lenalidomide, whereas the ?isoindolinone ring is exposed to solvent. The authors also solved the structures of the mouse TBD in the apo state and with ?thalidomide or ?pomalidomide. Site-directed mutagenesis in lentiviral-expression myeloma models showed that key drug-binding residues are critical for antiproliferative effects.

Chamberlain, Philip P., et al. "Structure of the human Cereblon–DDB1–lenalidomide complex reveals basis for responsiveness to thalidomide analogs."Nature structural & molecular biology (2014). doi:10.1038/nsmb.2874

5. New synchrotron imaging technique reveals how cystic fibrosis makes lungs vulnerable to infection 

University of Saskatchewan researchers working at the CLS BMIT beamline have developed a new imaging technique that reveals a hitherto unknown component of the immune system in the lungs, one that promises insights that could benefit cystic fibrosis patients. Their findings are published today in the Proceedings of the National Academy of Sciences (PNAS). 

Read the rest of the CLS news release on our website. 

 

 

6. Research gives further insight into graphene-based devices 

Using a number of experimental facilities at the CLS, a group of scientists successfully measured the smallest optical density of single layer graphene so far, giving further insight into the design and fabrication of graphene-based nanodevices, which can potentially enable the future electronic gadgets.

The research was recently published in ACS Nano. Read the rest of the CLS news release on our website.  

 

 

 

 

7. An interesting glimpse into how future of state-of-the-art electronics might work

Using the CLS, scientists have developed a new, cutting-edge technique enabling them to visualize the inner-workings of electronics.

This research is opening the door for a wide-range of opportunities for advanced nanoelectronics and devices. It could prove essential for the development of novel sensors for detecting light, magnetic fields and chemicals – which could be useful for medical analysis and treatments. New solar power harvesting capabilities might now be a step closer. 

The research was recently published in Advanced Materials. The complete news release is available on the CLS website. 

8. New staff and now hiring

We are pleased to announce two new employees who have recently joined the CLS.

Jarvis Stobbs recently joined the Experimental Facilities Division as a Science Associate – Experimental Floor. Jarvis relocated to Saskatoon from Estevan, SK, where he was completing a work term for his Chemical Technology diploma at the Boundary Dam Power Station.

 

 

 

Garth Steel recently joined Controls and Instrumentation Development as a Controls Analyst.  Garth’s most recent role was at Littelfuse Startco where he worked as a Computer Programmer.

 

 

 

 

The following job postings are currently available at CLS:

Job No. 769 – Mechanical Engineer
Job No. 767 – Mechanical Engineer
Job No. 764 – Quality Assurance

Please visit our careers page for more information.

 


CLS E-News is an electronic newsletter designed to keep users and stakeholders informed about developments at the Canadian Light Source. Current and past issues of CLS E-News are available on our website: http://www.lightsource.ca/news.html?q=4
To unsubscribe please go to http://www.lightsource.ca/news/signup.html. We welcome suggestions for topics and content. Contact us atcls@lightsource.ca

how can we help?

If you’re looking for information on how you can use CLS techniques in your research program, please contact us using this form.

Example queries may include: Feasibility around a potential experiment? A scientific problem we can help you solve? Is your question related to a specific technique? Do you want to know more about how to apply for beamtime?

Newsletter Signup

By providing your email address, you are expressing consent to receive electronic messages from the Canadian Light Source. You can unsubscribe from these messages at any time.

**Newsletters are sent approximately once a month**